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[18F]fluorobenzoyl-folate
- Development stage
- Unknown
- Lead developer
- Leiden University Medical Center
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[18F]fluorobenzoyl-folate (also known as [18F]SFB-FOL or [18F]fluoro-PEG-folate) is an investigational fluorine-18 labeled folate-receptor-targeted radiopharmaceutical used as a positron emission tomography (PET) imaging tracer. It binds with high affinity to both folate receptor alpha (FR-α) and folate receptor beta (FR-β). FR-α is overexpressed in various malignancies, such as epithelial ovarian cancer, while FR-β is highly expressed on activated macrophages at sites of active inflammation. Consequently, [18F]fluorobenzoyl-folate is being developed for the non-invasive detection and monitoring of inflammatory diseases, such as rheumatoid arthritis, giant cell arteritis, and myocarditis, as well as for the preoperative assessment of tumor load in epithelial ovarian cancer.
- Other names
- N-succinimidyl 4-[18F]fluorobenzoate-conjugated folateN-succinimidyl 4-[18F]fluorobenzoate-labeled folate[18F]F-PEG-folate[18F]F-SFB-folate[18F]Fluor-PEG-Folate[18F]fluoro-PEG-folate[18F]fluoro-PEG6-folate[18F]PEG-folate[18F]SFB-FOL
02
Targets
FOLR1 (FRα)FOLR2 (Folate receptor beta)
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